rheumatoid arthritis criteria for Dummies

Around the world, people are suffering more because their immune systems cannot discern between healthy cells and invading microorganisms. Instead of protecting themselves from disease their organs and tissues are being attacked by the same defenses.




This issue is being addressed by major international research initiatives. One instance of this initiative is at London's Francis Crick Institute. Two world experts, James Lee (from the USA) as well as Carola Vinuesa (from Italy) have formed distinct research groups to determine the exact causes.


Lee told the Observer that autoimmune illnesses began to increase about 40 years ago in western countries. We now see some cases in countries that had never experienced such illnesses.


The Middle East, East Asia and Africa have seen the highest increase in inflammatory bowel disorder cases in recent years. Before that they had hardly ever heard of the disease.


Type 1 diabetes is among the autoimmune diseases. Other diseases include rheumatoid disease, inflammation of the bowel, and multiple sclerosis. In all instances, the immune system is activated and turns on healthy tissues.


The UK has at least 4,000,000 people who have these conditions. There are also many others. In the world, it is believed that the amount of autoimmune disease is increasing by between 3 and 9 percent each year. The rise in cases of autoimmune diseases is believed to be caused by environmental factors, as per the majority of experts.


Lee who worked previously at Cambridge University, said that the human genetic makeup hasn't changed in the last decade. It seems that something is taking place in the world outside that is increasing our susceptibility to autoimmune diseases.


Vinuesa was the one who backed this notion. Vinuesa was previously at the Australian National University. She spoke about the changes in diets that occurred as more countries adopted west-style diets and people ate more fast foods.


Vinuesa said that fast food meals lack some important ingredients such as fiber. The evidence suggests that this alteration can influence the microbiome of an individual, which is the collection of microorganisms that reside in our digestive tract. These microorganisms play a vital role in regulating many bodily functions.


The changes in our microbiomes then cause autoimmune diseases There are more than 100 types.


Both researchers emphasized that individual susceptibilities were involved in contracting such illnesses, ailments that also include celiac disease as with lupus, which causes swelling and inflammation that can cause harm to different organs, including the heart.


Vinuesa stated "If you don’t have a genetic susceptibility to autoimmune diseases, you won’t necessarily get one, regardless of how many Big Macs you eat." There is nothing we can change the widespread rapid expansion of fast food chains across the globe. Instead, we are focusing on understanding the genetic factors that underlie autoimmune disorders and why some individuals are susceptible while others are not. This is how we want to tackle the issue."


This task is possible thanks to the development of techniques that now allow scientists to pinpoint tiny DNA differences among large numbers of individuals. It is possible to determine common genetic patterns that are common to individuals suffering from an autoimmune condition.


Up until recently we didn't have the tools for this, but we're able to analyze DNA on a massive scale, and it has transformed everything, explained Lee. When I first began my research at the time, Check out we had only a glimpse of half of the DNA variations that are involved in the development of inflammation in the intestines. Over 250 of them are identified.


This is the heart of the research conducted by Lee and Vinuesa. They are trying to understand how different genetic pathways function and to discover the different kinds of diseases that researchers are currently studying. Vinuesa explained that there may be multiple versions of certain diseases that are autoimmune, such as Lupus. This is a problem when trying to find the right treatment.


There are a lot of new therapies that are likely to be beneficial but we don't have the appropriate patients. Actually we do not have the necessary information to know if they have the same illness. This is an important goal in research into autoimmune diseases. It is essential to learn how to stratify and group patients so that you can give them the right therapy.


Lee stated that due to the increase in autoimmune diseases all over the world, new therapies and medicines are required more urgently than ever. Lee also said that there's currently no cure for the autoimmune diseases. These often are seen in children as they try to finish their education, find work, and then start families.


This means that a rising amount of people need surgery or require injections regularly throughout the rest of their lives. It can be very challenging for patients and place a strain on the health system. This is why we need to come up with innovative, efficient treatment options.


Rheumatoid arthritis is an autoimmune condition, which means it's due to the immune system attacking healthy body tissues. This is an unanswered mystery.


Your immune system naturally creates antibodies to fight bacteria and viruses.


Rheumatoid arthritis is a disease in which your immune system sends antibodies to your joints. They attack the joint tissue surrounding the joint.


The thin layer, or synovium, of cells that cover your joints to become painful. The synovium also releases chemicals that could cause injury to your nearby.


bones

Cartilage – The connective tissue that is stretchy and connects bones

Tendons are the connective tissue that connects bone and muscle.

Ligaments - The tissues that connects bone to cartilage

Rheumatoid arthritis can be treated but it is not managed. The chemicals that cause it cause the joint to become dislocated and out of alignment. The joint can end up being destroyed. joint.


Though there are many theories on how the immune system is attacking joints, none have been proved.

Possible risk factors

You could be more at risk of developing rheumatoid arthritis If you have the following habits:


The genes you carry - There is evidence that suggests that rheumatoid joint disease can be passed down in families. But, it's unlikely that you'll inherit the condition. Genes are thought to only play Check out a minor part in the.

Hormones Rheumatoid arthritis can be more common for women than men. Though this could be due in part to the effect of the estrogenic hormones on the body, it has not been proven.

Smoking cigarettes - There is evidence that smoking increases the likelihood of developing rheumatoid arthritis.